† = equal contribution
* = corresponding author

Pre-prints in review

  • Photoswitchable binders enable temporal dissection of endogenous protein function

    *,†M. Westberg, †D. Song, V. Duong, D. Fernandez, P. Huang, *M. Z. Lin

    bioRxiv 2023, DOI: 10.1101/2023.09.14.557687


  • An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations

    *M. Westberg, Y. Su, X. Zou, P. Huang, A. Rustagi, J. Garhyan, P. B. Patel, D. Fernandez, Y. Wu, C. Hao, C.-W. Lo, M. Karim, L. Ning, A. Beck, P. Saenkham-Huntsinger, V. Tat, A. Drelich, B. Peng, S. Einav, C. K. Tseng, C. Blish, *M. Z. Lin

    Science Translational Medicine 2024, 16, DOI: 10.1126/scitranslmed.adi097 , eadi0979

  • Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

    †Y. Wu Y, J. Walker, M. Westberg, L. Ning, M. Monje, T. Kirkland, *M. Z. Lin, *,†Y. Su

    ACS Cent. Sci 2023, 9, DOI: 10.1021/acscentsci.3c00074 , 719-732

  • A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3

    B. B. Kim, H. Wu, Y. A. Hao, M. Pan, M. Chavarha, M. Westberg, F. St-Pierre, J. C. Wu, *M. Z. Lin

    Sci. Rep. 2022, 12, DOI: 10.1038/s41598-022-07313-1 , 3678

  • Stable Transfection of the Singlet Oxygen Photosensitizing Protein SOPP3: Examining Aspects of Intracellular Behavior

    D. J. Mogensen, M. Westberg, T. Breitenbach, M. Etzerodt, and *P.R. Ogilby

    Photochem. Photobiol. 2021, 97, DOI: 10.1111/php.13440 , 1417-1430

  • Photophysics of a protein-bound derivative of malachite green that sensitizes the production of singlet oxygen

    L. Dichmann, M. Bregnhøj, H. Liu, M. Westberg, T. B. Poulsen, M. Etzerodt, *P. R. Ogilby

    Photochem. Photobiol. Sci. 2021, 20, DOI: 10.1007/s43630-021-00032-y , 435-449

  • Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases

    M. Westberg, Y. Su, X. Zou, L. Ning, B. Hurst, B. Tarbet, *M. Z. Lin

    bioRxiv 2020, DOI: 10.1101/2020.09.15.275891

  • Light-initiated oxidative stress

    A. Blázquez-Castro, M. Westberg, M. Bregnhøj, T. Breitenbach, D. J. Mogensen, M. Etzerodt, *P. R. Ogilby

    Oxidative Stress, Academic Press 2020, DOI: 10.1016/B978-0-12-818606-0.00019-5 , 363-388

  • Rational Design of Genetically Encoded Singlet Oxygen Photosensitizing Proteins

    M. Westberg, M. Etzerodt, *P. R. Ogilby

    Curr. Op. Struct. Biol. 2019, 57, DOI: 10.1016/ , 56-62

  • Single mutation in a novel bacterial LOV protein yields a singlet oxygen generator

    E. Consiglieri, Q. Xu, M. Bregnhøj, M. Westberg, P. R. Ogilby, *A. Losi

    Photochem. Photobiol. Sci. 2019, 18, DOI: 10.1039/C9PP00328B , 2657-2660

  • Uric Acid: A Less-than-Perfect Probe for Singlet Oxygen

    M. Bregnhøj, L. Dichmann, C. K. McLoughlin, M. Westberg, *P. R. Ogilby

    Photochem. Photobiol. 2019, 95, DOI: 10.1111/php.12971 , 202-210

  • Azadioxatriangulenium and Diazaoxatriangulenium: Quantum Yields and Fundamental Photophysical Properties

    S. A. Bogh, M. Simmermacher, M. Westberg, M. Bregnhøj, M. Rosenberg, L. De Vico, M. Veiga, B. W. Laursen, P. R. Ogilby, S. P. Sauer, *T. J. Sørensen

    ACS Omega 2017, 2, DOI: 10.1021/acsomega.6b00211 , 193-203

  • Temperature Sensitive Singlet Oxygen Photosensitization by LOV-Derived Fluorescent Flavoproteins

    M. Westberg, M. Bregnhøj, M. Etzerodt, *P. R. Ogilby

    J. Phys. Chem. B 2017, 121, DOI: 10.1021/acs.jpcb.7b00561 , 2561-2574

  • Singlet Oxygen Photophysics in Liquid Solvents: Converging on a Unified Picture

    M. Bregnhøj, M. Westberg, B. Minaev, *P. R. Ogilby

    Acc. Chem. Res. 2017, 50, DOI: 10.1021/acs.accounts.7b00169 , 1920-1927

  • Monitoring Interfacial Lipid Oxidation in Oil-in-Water Emulsions using Spatially-Resolved Optical Techniques

    C. Banerjee, M. Westberg, T. Breitenbach, M. Bregnhøj, *P. R. Ogilby

    Anal. Chem. 2017, 89, DOI: 10.1021/acs.analchem.7b01228 , 6239–6247

  • No Photon Wasted: An Efficient and Selective Singlet Oxygen Photosensitizing Protein

    M. Westberg, M. Bregnhøj, M. Etzerodt, *P. R. Ogilby

    J. Phys. Chem. B 2017, 121, DOI: 10.1021/acs.jpcb.7b07831 , 9366-9371

  • A Ligand Substituted Tungsten Iodide Cluster: Luminescence vs. Singlet Oxygen Production

    L. Riehl, A. Seyboldt, M. Ströbele, D. Enseling, T. Jüstel, M. Westberg, P. R. Ogilby, *H. J. Meyer

    Dalton Transactions 2016, 45, DOI: 10.1039/C6DT02471H , 15500-15506

  • Solvent-Dependent Singlet Oxygen Lifetimes: Temperature Effects Implicate Tunneling and Charge-Transfer Interactions

    M. Bregnhøj, M. Westberg, F. Jensen, *P. R. Ogilby

    Phys. Chem. Chem. Phys. 2016, 18, DOI: 10.1039/C6CP01635A , 22946-22961

  • Intracellular Singlet Oxygen Photosensitizers: On the Road to Solving the Problems of Sensitizer Degradation, Bleaching and Relocalization

    E. F. F. da Silva, F. M. Pimenta, B. W. Pedersen, F. H. Blaikie, G. N. Bosio, T. Breitenbach, M. Westberg, M. Bregnhøj, M. Etzerodt, *L. G. Arnaut, *P. R. Ogilby

    Integrative Biology 2016, 8, DOI: 10.1039/C5IB00295H , 177-193

  • Control of Singlet Oxygen Production in Experiments Performed on Single Mammalian Cells

    M. Westberg, M. Bregnhøj, A. Blázquez-Castro, T. Breitenbach, M. Etzerodt, *P. R. Ogilby

    J. Photochem. Photobiol. A Chem. 2016, 321, DOI: 10.1016/j.jphotochem.2016.01.028 , 297–308

  • Solvent and Heavy-Atom Effects on the O2(X3Σg–) → O2(b1Σg+) Absorption Transition

    M. Bregnhøj, M. V. Krægpøth, R. J. Sørensen, M. Westberg, *P. R. Ogilby

    J. Phys. Chem. A 2016, 120, DOI: 10.1021/acs.jpca.6b08035 , 8285-8296

  • Exerting Better Control and Specificity with Singlet Oxygen Experiments in Live Mammalian Cells

    M. Westberg, M. Bregnhøj, C. Banerjee, A. Blázquez-Castro, T. Breitenbach, *P. R. Ogilby

    Methods 2016, 109, DOI: 10.1016/j.ymeth.2016.07.001 , 81-91

  • Towards Quantification of Vibronic Coupling in Photosynthetic Antenna Complexes

    V. P. Singh, M. Westberg, C. Wang, P. D. Dahlberg, T. Gellen, A. T. Gardiner, R. J. Cogdell, *G. S. Engel

    J. Chem. Phys. 2015, 142, DOI: 10.1063/1.4921324 , 212446

  • Rational Design of an Efficient, Genetically Encodable, Protein-Encased Singlet Oxygen Photosensitizer

    M. Westberg, L. Holmegaard, F. M. Pimenta, M. Etzerodt, *P. R. Ogilby

    J. Am. Chem. Soc. 2015, 137, DOI: 10.1021/ja511940j , 1632-1642

  • Solvent Dependent Photosensitized Singlet Oxygen Production from an Ir(III) Complex: Pointing to Problems in Studies of Singlet-Oxygen-Mediated Cell Death

    S. Takizawa, T. Breitenbach, M. Westberg, L. Holmegaard, A.Gollmer, R. L. Jensen, S. Murataa, *P. R. Ogilby

    Photochem. Photobiol. Sci. 2015, 14, DOI: 10.1039/C5PP00230C , 1831-1843

  • Direct 765 nm Optical Excitation of Molecular Oxygen in Solution and in Single Mammalian Cells

    M. Bregnhøj, A. Blázquez-Castro, M. Westberg, T. Breitenbach, *P. R. Ogilby

    J. Phys. Chem. B 2015, 119, DOI: 10.1021/acs.jpcb.5b01727 , 5422-5429

  • Singlet-Oxygen-Mediated Cell Death using Spatially-Localized Two-Photon Excitation of an Extracellular Sensitizer

    F. M. Pimenta, R. L. Jensen, L. Holmegaard, T. V. Esipova, M. Westberg, T. Breitenbach, *P. R. Ogilby

    J. Phys. Chem. B 2012, 116, DOI: 10.1021/jp304954m , 10234-10246